1-MNA is an endogenous active substance of vitamin origin, physiologically present in humans. It exists as a quaternary pyridinium salt and is a major metabolite of vitamin B3. 1-MNA is produced in humans as a result of vitamin B3 metabolism in the liver. This metabolite is found in very few food products. Wakame brown algae (Undaria pinnatifida) along with green tea leaves (Camellia sinensis) are the richest known sources of 1-MNA. However, they are not considered practical 1-MNA sources for humans. As the physiological metabolism of vitamin B3 into 1-MNA decreases with age, dietary supplementation with 1-MNA is particularly recommended in the elderly.
1-MNA has been assessed in detail by the European Food Safety Authority (EFSA). Scientific evaluation showed that 1-MNA is safe to use*.
* EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D et all., Scientific Opinion, Safety of 1- methylnicotinamide chloride (1-MNA) as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal 2017;15(10): 5001.